Long noncoding RNA in gastric juice, plasma may be marker for gastric cancer

Changes in long noncoding RNA-AA174084 levels in the tissues, gastric juice and plasma of patients with gastric cancer were associated with clinicopathological factors, suggesting utility as a biomarker for early screening and predicting prognoses, according to research data.

To determine the diagnostic and prognostic utility of plasma and gastric juice levels of AA174084 (AA) — a long noncoding RNA (lncRNA) found with abnormal expression in gastric cancer (GC) tissues in a previous study — researchers analyzed samples from three gastroenterology centers in China from February 2011 to November 2013. Total RNA was extracted from 860 patients and controls and measured using real-time reverse transcriptase-polymerase chain reaction analysis.