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orphan drug

MacroGenics Announces Margetuximab Granted Orphan Drug Designation in the U.S. for Gastric Cancer

MacroGenics received orphan drug designation from the FDA for its investigational gastric cancer drug margetuximab.

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Gastric Cancer Foundation

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Gastric Cancer Foundation

6 hours ago

In preclinical studies, combining the experimental drug pelcitoclax with chemotherapy was effective against HER2-positive gastric cancer. The drug is designed to overcome resistance to HER2-targeted drugs by binding to two tumor targets and inducing the death of cancer cells. ... See MoreSee Less

The novel BCL-2/BCL-XL inhibitor APG-1252-mediated cleavage of GSDME enhances the antitumor efficacy of HER2-targeted therapy in HER2-positive gastric cancer - Acta Pharmacologica Sinica

www.nature.com

HER2-positive gastric cancer has a poor prognosis, with a high incidence of drug resistance and a lack of effective treatments for drug-resistant patients. The exploration of the mechanism of resistan...

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Gastric Cancer Foundation

1 day ago

In clinical trials, the multi-kinase inhibitor Stivarga (regorafenib) produced an improvement in overall survival in patients with refractory advanced gastric cancer. The drug is currently on the market to treat colorectal cancer, gastrointestinal stromal tumors and hepatocellular carcinoma. Investigators believe the results show the drug improves quality of life and delays disease progression, and that it could prove effective in combination with chemotherapy and immunotherapy. ... See MoreSee Less

Regorafenib Provides Modest Survival Benefit in Refractory Advanced Gastric/GEJ Cancer

www.onclive.com

Regorafenib improved overall survival vs placebo in refractory advanced gastric or gastroesophageal junction cancer.

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Gastric Cancer Foundation

4 days ago

When combined with best supportive care, the multi-kinase inhibitor regorafenib produced improvements in both overall survival and progression-free survival in a trial that included gastric cancer patients.www.oncologynewscentral.com/article/regorafenib-improves-survival-in-hard-to-treat-gastric-cancer ... See MoreSee Less

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Gastric Cancer Foundation

1 week ago

Tune in for another in our Foodie Friday series focusing on healthy eating during the holidays! With Christmas around the corner, Chef Hans shares a delicious, nutritious recipe for rainbow roasted carrots. Be on the lookout for Hans' "quick seasoning" salt recipe that results in a quick, easy, dish full of essential vitamins. gastriccancer.org/video/roasted-rainbow-carrots/ ... See MoreSee Less

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Gastric Cancer Foundation

1 week ago

“We are increasingly understanding that gastric cancer is more than one disease,” says John L. Marshall, chief medical officer of the Lombardi Comprehensive Cancer Center at Georgetown University. Learn more in this video from Cancer Network. ... See MoreSee Less

Different Treatment Algorithms for Gastric Cancers May Improve Outcomes

www.cancernetwork.com

Additional genetic testing measures and targeted therapies may improve outcomes for patients with diverse molecular subgroups of gastric cancers.

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