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News in Gastric Cancer

News from around the world, curated by the Gastric Cancer Foundation.

DNA genes familial gastric cancer

ctDNA Identifies Acquired Resistance Mechanisms to Savolitinib in MET+ Gastric Cancer

An early trial of AstraZeneca’s MET inhibitor savolitinib in gastric cancer revealed mutations that confer drug resistance.

clinical trials, drugs, mutations, resistance

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GCF-AGA Grant Awards Newest Research Scholar: Samuel J Klempner, MD

FDA Grants Full Approval of Deciphera Pharmaceuticals’ QINLOCK™ (ripretinib) for the Treatment of Fourth-Line Gastrointestinal Stromal Tumor

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For press inquiries about the Gastric Cancer Foundation, please contact: Mediainfo@gastriccancer.org

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Gastric Cancer Foundation

22 hours ago

The FDA approved BeiGene’s Tevimbra plus chemotherapy to treat metastatic gastric cancer. The approval was based on trial data showing a clinically meaningful improvement in overall survival. ... See MoreSee Less

Tislelizumab Plus Chemotherapy Receives FDA Approval for First-Line Treatment of Advanced Gastric Cancer

www.oncnursingnews.com

The FDA approved tislelizumab plus chemotherapy for the first-line treatment of unresectable or metastatic gastric or GEJ adenocarcinoma.

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Gastric Cancer Foundation

4 days ago

At American Society of Clinical Oncology Gastrointestinal Cancers Symposium 2025, Agenus will discuss its investigative treatment combining two antibodies with natural killer T cells in gastric cancer. ... See MoreSee Less

Agenus Announces Five Presentations at ASCO GI Highlighting BOT/BAL Activity Across Colorectal and Gastric Cancers

www.biospace.com

Presentations will showcase new data reinforcing BOT/BAL’s potential across different lines of treatment in colorectal cancer, including the neoadjuvant setting

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Gastric Cancer Foundation

3 weeks ago

Researchers at Cleveland Clinic developed a machine learning model that uses data from electronic health records to find patients most at risk for gastric cancer. The model incorporated data from 11,000 patients—including 567 with gastric cancer—and predicted gastric cancer risk with surprising accuracy. Researchers reported at the 2024 American College of Gastroenterology Annual Scientific Meeting. ... See MoreSee Less

Model Uses Machine Learning to Predict Patients at Risk of Gastric Cancer

consultqd.clevelandclinic.org

New research from Cleveland Clinic shows how a machine learning model could help clinicians better identify patients with a high risk for gastric cancer.

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Gastric Cancer Foundation

3 weeks ago

Researchers at the MD Anderson Cancer Center discovered an enzyme, SMYD5, that fuels cancer growth by stimulating the production of certain proteins. They found that in mouse models of gastric cancer, targeting SMYD5 slowed down tumor growth and improved the efficacy of CAR-T cell therapy. ... See MoreSee Less

Enzyme discovery heralds new target for gastric cancer treatment

www.nature.com

Blocking enzyme SMYD5 inhibits tumour growth and primes lab models for combination therapy, offering hope for more effective treatments.

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Gastric Cancer Foundation

4 weeks ago

In preclinical studies, combining the experimental drug pelcitoclax with chemotherapy was effective against HER2-positive gastric cancer. The drug is designed to overcome resistance to HER2-targeted drugs by binding to two tumor targets and inducing the death of cancer cells. ... See MoreSee Less

The novel BCL-2/BCL-XL inhibitor APG-1252-mediated cleavage of GSDME enhances the antitumor efficacy of HER2-targeted therapy in HER2-positive gastric cancer - Acta Pharmacologica Sinica

www.nature.com

HER2-positive gastric cancer has a poor prognosis, with a high incidence of drug resistance and a lack of effective treatments for drug-resistant patients. The exploration of the mechanism of resistan...

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