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Learn about Gastric Cancer

Learn how gastric cancer develops, how it’s diagnosed, and the latest information on treatment options and supportive care.

Information can be powerful. Whether you’re a patient, caregiver, or simply wanting to know more about this disease, you’re in the right place.

The content on this website is for your general knowledge and is not intended to replace professional medical advice, diagnosis, or treatment. We encourage you to consult with qualified healthcare professionals for guidance and care tailored to your specific needs.

Diagnosing Gastric Cancer

If your doctor suspects that you have gastric cancer, they will ask about your health history, conduct lab tests, and refer you to a gastroenterologist for diagnosis and treatment.

Types of Diagnostic Tests

Physical Exam

Your doctor examines your abdomen, gently feeling for fluid, swelling, or any unusual changes. They may also check the size of your lymph nodes, which are small glands that can swell during an immune system response.

Endoscopy

An endoscopy allows the doctor to see the inside of your stomach. First, your doctor will administer a sedative to help you relax and minimize discomfort during the procedure. This sedation, often combined with a numbing medicine (anesthetic), will dull any feeling in your throat and help prevent gagging as the endoscope is inserted. Then, they will insert a lighted, flexible tube with a tiny camera into your mouth and down your throat (esophagus) to examine your stomach.

“An endoscopy allows the doctor to see the inside of your stomach. First, your doctor will administer a sedative to help you relax and minimize discomfort during the procedure. This sedation, often combined with a numbing medicine (anesthetic), will dull any feeling in your throat and help prevent gagging as the endoscope is inserted. Then, they will gently insert a lighted, flexible tube with a tiny camera into your mouth and down your throat (esophagus) to examine the area.”

Biopsy

Your doctor uses a long, flexible tube with a tiny camera and light at the end (endoscope) to take a small sample of your stomach tissue. A pathologist will then examine this sample under a microscope to check for cancer cells. Having a biopsy done is the only way to know for certain whether cancer cells are present in the tissue.

CT Scan

An x-ray machine captures detailed images of your organs and projects them to a computer screen. You might also get an injection of dye to enhance visibility of abnormal areas. Tumors that have spread to your liver, pancreas, or elsewhere in the body can show up on a CT scan.

Barium Swallow

A barium swallow is an X-ray test that is less invasive than an endoscopy. First, you swallow a chalky solution that contains barium, a silver-white metallic substance. The barium coats the inner lining of your stomach, esophagus, and small intestine. When the doctor views the X ray, the barium coating helps your doctors see any abnormalities in the lining of these organs.

Chest X-Ray

Similar to a CT scan, this test involves using an x-ray machine to create a visual image of the inside of your chest. This can be used to determine if tumors have spread into your lungs.

Endoscopic Ultrasound

Similar to an endoscopy, your doctor guides a thin, illuminated tube (endoscope) down your throat. However, in an endoscopic ultrasound, the endoscope has a small sensor on the end that releases inaudible sound waves, which bounce off your stomach tissues and organs. A computer then creates a picture from these echoes, revealing the depth of cancer invasion within the stomach wall. Your doctor might also use a needle to take tissue samples from your lymph nodes. Endoscopic ultrasounds are used for staging your condition.

Laparoscopy

A surgeon creates small incisions in your abdomen and uses a thin, lit tube (laparoscope) to explore and remove tissue samples for further examination. A laparoscopy test may be used for staging your condition.

PET (Positron emission tomography) Scan

A PET scan can be used to determine the extent of the cancer in the body. For this test, you are injected with a slightly radioactive form of sugar, which collects mainly in cancer cells. A special camera is then used to create a picture of areas of radioactivity in the body. The picture is not detailed like a CT or MRI scan, but a PET scan can look for possible areas of cancer spread in all areas of the body at once.

Many newer machines can do both a PET and CT scan at the same time (PET/CT scan). This lets the doctor see areas that “light up” on the PET scan in more detail.

Don’t delay. Talk to your doctor about getting tested for biomarkers.

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Biomarker Testing

Why is testing biomarkers important in gastric cancer treatment?

In the past, everyone with a specific type of cancer received similar drug or surgery plans, but new research has shown that tumors, even within the same cancer type, can differ among patients. Doctors can now provide personalized and improved care by matching treatments to a patient’s unique set of biomarkers. Gastric cancer biomarkers can include genes, proteins or specific substances produced by the tumor.

To learn more about specific biomarkers that are used to treat gastric cancer, visit our Biomarkers and Gastric Cancer page.

Staging

Staging is a process that helps doctors decide what type of treatment options are best for your condition. The different stages of cancer progression are based on how much the tumor has moved into the stomach wall, if it has spread to nearby tissues, and whether there is potential for the cancer to spread to other parts of the body.

Stage 0

The tumor is found only in the inner layer of the stomach.

Stage I

The cancer has only spread into the stomach wall’s inner layers or the outer muscle layers. It may have also spread to one or two lymph nodes.

The tumor has invaded only the submucosa (thick layer of loose connective tissue underneath the layer of the stomach that secretes mucus/acids). Cancer cells may be found in up to 6 lymph nodes. Or, the tumor has invaded the muscle layer or subserosa (layer of tissue between the outermost layer of the stomach wall and the muscle layer). Cancer cells have not spread to lymph nodes or other organs.

Stage II

The tumor has grown into deeper layers of the stomach wall. Cancer has spread to some lymph nodes but not to other parts of the body.

The tumor has invaded only the submucosa (thick layer of loose connective tissue underneath the layer of the stomach that secretes mucus/acids). Cancer cells have spread to 7 to 15 lymph nodes.
Or, the tumor has invaded the muscle layer or subserosa (layer of tissue between the outermost layer of the stomach wall and the muscle layer). Cancer cells have spread to 1 to 6 lymph nodes.
Or, the tumor has penetrated the outer layer of the stomach. Cancer cells have not spread to lymph nodes or other organs.

Stage III

The tumor is larger, growing through layers of the stomach and into connective tissue outside the stomach. The cancer has spread to some lymph nodes but hasn’t spread beyond the stomach.

The tumor has invaded the muscle layer or subserosa (layer of tissue between the outermost layer of the stomach wall and the muscle layer). Cancer cells have spread to 7 to 15 lymph nodes.
Or, the tumor has penetrated the outer layer. Cancer cells have spread to 1 to 15 lymph nodes.
Or, the tumor has invaded nearby organs, such as the liver, colon, or spleen. Cancer cells have not spread to lymph nodes or to distant organs.

Stage IV

The cancer has spread to other organs beyond the stomach. It may have also spread to more than 15 lymph nodes.

Cancer cells have spread to more than 15 lymph nodes.
Or, the tumor has invaded nearby organs and at least 1 lymph node.
Or, cancer cells have spread to distant organs.

Second Opinion

Consider getting a second opinion from another healthcare professional before starting treatment.

Before starting treatment, you might want a second opinion from another doctor about your diagnosis and treatment plan. Some people worry that their doctor will be offended if they ask for a second opinion. Usually the opposite is true. Most doctors welcome a second opinion. And many health insurance companies will pay for a second opinion if you or your doctor requests it. Some companies require a second opinion.
If you get a second opinion, the doctor may agree with your first doctor’s diagnosis and treatment plan. Or the second doctor may suggest another approach. Either way, you’ll have more information and perhaps a greater sense of control. You may also feel more confident about the decisions you make, knowing that you’ve looked carefully at your options.
Seeking a second opinion is a proactive step that can empower you to make informed decisions about your healthcare journey. A second doctor could confirm your original diagnosis, propose a different diagnosis, or suggest additional treatment options. Having a second opinion lets you learn more about your diagnosis and allows you to make the best decision for your situation.

Gastric cancer is a complex condition that requires a multidisciplinary treatment team. To get a comprehensive assessment of your condition, try to visit a cancer center, as they often incorporate a collaborative approach into treatment planning. Alternatively, you should consider seeking out a specialist in gastroenterological cancer for recommendations.

I have been diagnosed with gastric cancer… What now?

There are many options to consider in your treatment planning. We are here to help you navigate next steps with your healthcare team.

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